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Invitrogen
NLRC4 Polyclonal Antibody
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FIGURE: 1 / 2
NLRC4 Antibody (PA5-72977) in ICC/IF
Immunocytochemistry analysis of NLRC4 in HepG2 cells. Samples were incubated with NLRC4 polyclonal antibody (Product # PA5-72977) using a dilution of 1:250 followed by Dylight 488 (Green). Alpha tubulin and nuclei were counterstained against Dylight 550 (Red) and DAPI (Blue), respectively.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-72977
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to an internal portion of the human CARD12 protein (between residues 600-700).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.13 mg/mL
Amount
113 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 30% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
NLRC4 encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CARD, LRR, and NACHT-containing protein; caspase recruitment domain family, member 12; Caspase recruitment domain-containing protein 12; CED-4-like protein Clan; Ice protease-activating factor; Ipaf; NLR family CARD domain-containing protein 4
Gene Aliases: 9530011P19Rik; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; IPAF; NLRC4; UNQ6189/PRO20215
UniProt ID: (Mouse) Q3UP24
Entrez Gene ID: (Mouse) 268973
activation of innate immune response
immune system process
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
regulation of signal transduction
detection of bacterium
protein ubiquitination
defense response to bacterium
regulation of apoptotic process
positive regulation of apoptotic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of neuron apoptotic process
innate immune response
interleukin-1 beta secretion
positive regulation of NF-kappaB transcription factor activity
protein homooligomerization
pyroptosis
mitotic spindle assembly
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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