Invitrogen

NLRP3 Monoclonal Antibody (nalpy3-b)

Name: NLRP3 Monoclonal Antibody (nalpy3-b)
Brand: Invitrogen
SKU: MA1-25943

查看其他26个NLRP3抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

NLRP3 Antibody in Immunohistochemistry (Frozen) (IHC (F))

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NLRP3 Antibody (MA1-25943) in IHC (F)

Immunohistochemistry (Frozen) analysis. Staining of endogenous NLRP3/NALP3 in epithelial layer of human tonsil (frozen section) using NLRP3 Monoclonal Antibody (nalpy3-b) (Product # MA1-25943).

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产品信息

MA1-25943

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

免疫组化（冰冻） (IHC (F))

Assay-dependent

免疫沉淀 (IP)

1:50

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

nalpy3-b

抗原

Recombinant human NALP3/NLRP3.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

IgG fraction

保存液

PBS

内含物

0.02% sodium azide

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2152458

产品详细信息

MA1-25943 has a predicted molecular weight of ~118kDa.

靶标信息

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome, and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; CLR1.1; cold autoinflammatory syndrome 1 protein; Cold-induced autoinflammatory syndrome 1 protein; Cryopyrin; FLJ95925; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; NACHT, LRR and PYD containing protein 3; NACHT, LRR and PYD domains-containing protein 3; NLR family, pyrin domain containing 3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3; PYRIN-containing APAF1-like protein 1

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基因别名: AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCAS1; FCU; MWS; NALP3; NLRP3; PYPAF1

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UniProt ID: (Human) Q96P20

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Entrez Gene ID: (Human) 114548

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功能

protein binding ATP binding transcription factor binding peptidoglycan binding sequence-specific DNA binding non-motor microtubule binding protein

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