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Invitrogen

NME2 Polyclonal Antibody

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View all (35) NME2 antibodies

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Product Details

PA5-27488

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human nm23-H2. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol, 1% BSA

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2544964

Product Specific Information

Recommended positive controls: A549, H1299, HCT116, mouse brain.

Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (89%), Dog (93%), Pig (95%), Rabbit (100%), Chicken (94%), Rhesus Monkey (98%), Bovine (97%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) which encode a fusion protein consisting of sequence sharing identity with each individual gene product.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2.7.13.3; C-myc purine-binding transcription factor PUF; c-myc transcription factor; epididymis secretory sperm binding protein Li 155an; expressed in non-metastatic cells 2 protein; HEL-S-155an; Histidine protein kinase NDKB; NDK B; NDK2; NDP kinase B; NDPK2; nm23-H2; nm23-H2S product (putative NDP kinase); putative; nm23-M2; NME2; non-metastatic cells 2, protein (NM23) expressed in; non-metastatic cells 2, protein (NM23B) expressed in; Nucleoside diphoshate kinase 2; Nucleoside diphosphate kinase B; Nucleoside diphosphate kinases 2; nucleoside-diphosphate kinase 2; nucleotide diphosphate kinase B; P18

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Gene Aliases: NDK2; NDKB; NDPK-B; NDPKB; NM23-H2; nm23-M2; NM23B; NME2; PUF

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UniProt ID: (Human) P22392, (Mouse) Q01768

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Entrez Gene ID: (Human) 4831, (Mouse) 18103

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Function(s)
nucleotide binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding DNA binding nuclease activity nucleoside diphosphate kinase activity protein histidine kinase activity protein binding ATP binding kinase activity transferase activity GDP binding identical protein binding metal ion binding G-quadruplex DNA binding protein serine/threonine kinase activity fatty acid binding drug binding intermediate filament binding enzyme binding kinase
Process(es)
GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process cell adhesion integrin-mediated signaling pathway nucleotide metabolic process nucleoside triphosphate biosynthetic process regulation of apoptotic process negative regulation of apoptotic process positive regulation of keratinocyte differentiation regulation of epidermis development positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter ITP biosynthetic process positive regulation of epithelial cell proliferation positive regulation of DNA-templated transcription, initiation negative regulation of myeloid leukocyte differentiation purine nucleotide metabolic process nucleoside diphosphate phosphorylation pyrimidine nucleotide metabolic process positive regulation of neuron projection development phosphorylation positive regulation of cAMP biosynthetic process protein autophosphorylation protein oligomerization mitophagy in response to mitochondrial depolarization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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