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Invitrogen
NNT1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-68466
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from human NNT1 [aa 171-220].
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Predicted to react with Mouse and Rat samples.
靶标信息
NNT-1/BCSF-3 is a neurotrophic factor with B-cell-stimulating capabilities. Expressed in the lymph nodes and spleen, NNT-1/BCSF-3 activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member b (LIFR-b) by binding and inducing the tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss, and B cell hyperplasia associated with increases in serum IgG and IgM.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: b cell-stimulating factor 3; B-cell stimulating factor 3; B-cell-stimulating factor 3; BSF-3; Cardiotrophin-like cytokine factor 1; neurotrophin-1/B-cell stimulating factor-3; NNT-1; NNT-1/BSF-3; Novel neurotrophin-1
基因别名: BSF3; CLC; CLCF1; NNT-1; NNT1
UniProt ID: (Mouse) Q9QZM3
Entrez Gene ID: (Mouse) 56708, (Rat) 365395
positive regulation of immunoglobulin production
positive regulation of type 2 immune response
cell surface receptor signaling pathway
JAK-STAT cascade
positive regulation of cell proliferation
B cell differentiation
positive regulation of B cell proliferation
positive regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of neuron apoptotic process
positive regulation of isotype switching to IgE isotypes
positive regulation of astrocyte differentiation
regulation of inflammatory response
positive regulation of corticotropin-releasing hormone secretion
regulation of protein kinase B signaling
regulation of ERK1 and ERK2 cascade
negative regulation of motor neuron apoptotic process
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