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Invitrogen
NOD1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-17328
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues near the carboxy terminus of Nod1 protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
172 µg/mL
规格
17.2 µg
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD1 contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and ten tandem leucine-rich repeats (LRRs) in its C-terminus. The CARD is involved in apoptotic signaling, and NOD1 activates caspase-9 and NF-kappa-B. LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: caspase recruitment domain 4; Caspase recruitment domain-containing protein 4; hNod1; mNod1; Nucleotide-binding oligomerization domain-containing protein 1
基因别名: C230079P11; CARD4; F830007N14Rik; Nlrc1; NOD1; RGD1562269
UniProt ID: (Mouse) Q8BHB0
Entrez Gene ID: (Mouse) 107607, (Rat) 500133
immune system process
positive regulation of dendritic cell antigen processing and presentation
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
defense response
positive regulation of cell death
detection of bacterium
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of stress-activated MAPK cascade
intracellular signal transduction
interleukin-8 biosynthetic process
defense response to bacterium
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
innate immune response
positive regulation of JNK cascade
defense response to Gram-positive bacterium
positive regulation of nitric-oxide synthase activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of ERK1 and ERK2 cascade
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
