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Abnova
NOD1 Monoclonal Antibody (3F10)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00010392-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, lambda
分类
Monoclonal
类型
Antibody
克隆号
3F10
抗原
NOD1 (AAH40339, 1 a.a. approximately 93 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: MEEQGHSEME IIPSESHPHI QLLKSNRELL VTHIRNTQCL VDNLLKNDYF SAEDAEIVCA CPTQPDKVRK ILDLVQSKGE EVSEFFLYLL QQL
靶标信息
NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD1 contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and ten tandem leucine-rich repeats (LRRs) in its C-terminus. The CARD is involved in apoptotic signaling, and NOD1 activates caspase-9 and NF-kappa-B. LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Apaf-1/Ced-4 family member; caspase recruitment domain family, member 4; caspase recruitment domain-containing protein 4; CED-4/APAF-1 cell death family member; NLR family, CARD domain containing 1; NOD1; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1; unnamed protein product
基因别名: CARD4; CLR7.1; hNod1; NLRC1
UniProt ID: (Human) Q9Y239
Entrez Gene ID: (Human) 10392
positive regulation of cytokine production
pattern recognition receptor signaling pathway
positive regulation of dendritic cell antigen processing and presentation
apoptotic process
defense response
inflammatory response
signal transduction
detection of biotic stimulus
positive regulation of autophagy
detection of bacterium
positive regulation of interleukin-1 beta production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
response to endoplasmic reticulum stress
intracellular signal transduction
defense response to bacterium
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
defense response to Gram-negative bacterium
nucleotide-binding oligomerization domain containing 1 signaling pathway
cellular response to muramyl dipeptide
positive regulation of NIK/NF-kappaB signaling
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