Search

  • Contact Us
  • Quick Order

Rockland

NOD2 Polyclonal Antibody

View all (14) NOD2 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
NOD2 Polyclonal Antibody

Product Details

200-401-DC8

Applications
Tested Dilution
Publications

Western Blot (WB)

1-4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL
-

Immunocytochemistry (ICC/IF)

10 µg/mL
-

ELISA (ELISA)

1:10,000-1:40,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Anti-Rabbit NOD2 polyclonal antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to 16 amino acids at the N-terminus of human NOD2.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: caspase recruitment domain family, member 15; caspase recruitment domain protein 15; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1; NLR family, CARD domain containing 2; NOD 2; NOD-2; NOD-like receptor C2; NOD2 protein; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2; Nucleotide-binding oligomerization domain-containing protein 2; unnamed protein product

View more View less

Gene Aliases: ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2; NOD2B; PSORAS1; YAOS

View more View less

UniProt ID: (Human) Q9HC29

View more View less

Entrez Gene ID: (Human) 64127

View more View less

Function(s)
nucleotide binding actin binding protein binding ATP binding enzyme binding protein kinase binding Hsp70 protein binding muramyl dipeptide binding pattern recognition receptor activity peptidoglycan binding ubiquitin binding anion binding ADP binding macromolecular complex binding CARD domain binding Hsp90 protein binding carbohydrate derivative binding
Process(es)
temperature homeostasis pattern recognition receptor signaling pathway adaptive immune response immune system process positive regulation of dendritic cell antigen processing and presentation positive regulation of cytokine production involved in immune response positive regulation of dendritic cell cytokine production positive regulation of type 2 immune response autophagy defense response I-kappaB kinase/NF-kappaB signaling response to nutrient positive regulation of cell proliferation detection of biotic stimulus detection of bacterium maintenance of gastrointestinal epithelium regulation of appetite response to muramyl dipeptide detection of muramyl dipeptide positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade intracellular signal transduction intestinal stem cell homeostasis p38MAPK cascade defense response to bacterium regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade innate immune response positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of gamma-delta T cell activation host-mediated regulation of intestinal microbiota composition positive regulation of epithelial cell proliferation regulation of inflammatory response positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 2 signaling pathway protein K63-linked ubiquitination cellular response to lipopolysaccharide cellular response to peptidoglycan cellular response to muramyl dipeptide protein linear polyubiquitination antibacterial innate immune response positive regulation of cytokine production involved in inflammatory response positive regulation of NIK/NF-kappaB signaling positive regulation of mitophagy positive regulation of protein K63-linked ubiquitination negative regulation of macrophage apoptotic process
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support