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Rockland
NOD3 Polyclonal Antibody
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NOD3 Antibody (600-401-DC9) in ICC/IF
Immunofluorescence Microscopy of NOD3 antibody. Tissue: Jurkat cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: NOD3 antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: NOD3 is cytoplasmic. Staining: NOD3 as red fluorescent signal.
产品信息
600-401-DC9
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-NOD3 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid synthetic peptide near the internal region of human NOD3.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-βB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CARD15-like protein; caterpillar 16.2; Caterpiller 16.2; Caterpiller protein 16.2; CLR16.2; NACHT, LRR and CARD domains-containing protein 3; NLR family CARD domain-containing protein 3; NLR family, CARD domain containing 3; NLR family, CARD domain containing 3, pseudogene 1; NOD-like receptor C3; Nucleotide-binding oligomerization domain protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3; Protein NLRC3
基因别名: CLR16.2; D230007K08Rik; mFLJ00348; NLRC3; Nlrc3-ps1; NOD3; RGD1304902
UniProt ID: (Human) Q7RTR2, (Mouse) Q5DU56
Entrez Gene ID: (Human) 197358, (Rat) 287070, (Mouse) 268857
I-kappaB kinase/NF-kappaB signaling
negative regulation of NF-kappaB transcription factor activity
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
T cell activation
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein ubiquitination
response to lipopolysaccharide
