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Invitrogen
NOS1AP Polyclonal Antibody
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产品信息
PA5-63147
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: KKKSQAMRIV RTVGQAFEVC HKLSLQHTQQ NADGQEDGES ERNSNSSGDP GRQLTGAERA STATAEETDI DAVEVPLPGN DV
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.
靶标信息
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON); C-terminal PDZ ligand of neuronal nitric oxide synthase protein; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain; MGC138500; nitric oxide synthase 1 (neuronal) adaptor protein; Nitric oxide synthase 1 adaptor protein
基因别名: 6330408P19Rik; CAPON; KIAA0464; NOS1AP
UniProt ID: (Human) O75052
Entrez Gene ID: (Human) 9722
regulation of heart rate by chemical signal
positive regulation of gene expression
positive regulation of nitric oxide mediated signal transduction
regulation of apoptotic process
regulation of nitric oxide biosynthetic process
positive regulation of nitric oxide biosynthetic process
regulation of nitric-oxide synthase activity
positive regulation of nitric-oxide synthase activity
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of cardiac muscle cell action potential
positive regulation of potassium ion transmembrane transport
regulation of high voltage-gated calcium channel activity
positive regulation of delayed rectifier potassium channel activity
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
positive regulation of peptidyl-cysteine S-nitrosylation
