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Invitrogen

NOTCH2 Polyclonal Antibody

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NOTCH2 Polyclonal Antibody

Product Details

PA5149980

Applications
Tested Dilution
Publications

Western Blot (WB)

0.01-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5-20 µg/mL
-

Immunocytochemistry (ICC/IF)

5-20 µg/mL
-
Product Specifications

Species Reactivity

Human, Pig, Rat

Host/Isotype

Rabbit

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Notch Homolog 2 (NOTCH2) (Ala2251-Asn2466)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3716015

Target Information

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: membrane bound receptor; Neurogenic locus notch homolog protein 2; neurogenic locus notch-like protein 2; Notch 2; notch gene homolog 2; Notch homolog 2; putative cell-fate determining protein; transmembrane protein; unnamed protein product

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Gene Aliases: AGS2; HJCYS; hN2; NOTCH2

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UniProt ID: (Human) Q04721

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Entrez Gene ID: (Human) 4853, (Pig) 100153369, (Rat) 29492

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Function(s)
transcription coactivator activity calcium ion binding protein binding enzyme binding signaling receptor activity NF-kappaB binding receptor activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development cell fate determination liver development placenta development heart looping morphogenesis of an epithelial sheet marginal zone B cell differentiation inflammatory response to antigenic stimulus atrioventricular node development pulmonary valve morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process humoral immune response Notch signaling pathway determination of left/right symmetry nervous system development axon guidance cell proliferation positive regulation of cell proliferation organ morphogenesis negative regulation of macromolecule biosynthetic process negative regulation of gene expression positive regulation of keratinocyte proliferation hemopoiesis cell differentiation embryonic limb morphogenesis BMP signaling pathway positive regulation of BMP signaling pathway multicellular organism growth intracellular signal transduction intrahepatic bile duct development wound healing defense response to bacterium regulation of apoptotic process myeloid dendritic cell differentiation positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of Ras protein signal transduction bone remodeling regulation of developmental process positive regulation of smooth muscle cell differentiation cardiac septum morphogenesis atrial septum morphogenesis placenta blood vessel development ciliary body morphogenesis positive regulation of ERK1 and ERK2 cascade left/right axis specification cellular response to tumor cell proximal tubule development glomerular visceral epithelial cell development glomerular capillary formation hepatocyte proliferation liver morphogenesis positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of hemopoiesis cholangiocyte proliferation regulation of osteoclast development transcription, DNA-templated cell cycle arrest negative regulation of cell proliferation cell growth tissue regeneration interleukin-4 secretion
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