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Invitrogen
NOTCH2 (Cleaved Asp1733) Polyclonal Antibody
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NOTCH2 (Cleaved Asp1733) Antibody (PA5-99443) in WB
Western blot analysis of NOTCH2 (Cleaved Asp1733) in 293 cell extract treated with TNF-alpha (left lane: treated with the antigen-specific peptide). Samples were incubated with NOTCH2 (Cleaved Asp1733) polyclonal antibody (Product # PA5-99443).
产品信息
PA5-99443
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NOTCH2(Accession Q04721), corresponding to amino acid residues L1717-S1741.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of fragment of activated Notch2 resulting from cleavage adjacent to Asp1733.
靶标信息
NOTCH2 (Cleaved Asp1733) refers to the activated intracellular domain of the Notch2 receptor generated following gamma-secretase-mediated proteolytic cleavage at aspartic acid residue 1733. NOTCH2 is encoded by the NOTCH2 gene and functions as a single-pass transmembrane receptor in the conserved Notch signaling pathway, which regulates cell fate determination, differentiation, proliferation, and survival. Upon ligand engagement by Delta-like or Jagged family members on adjacent cells, NOTCH2 undergoes sequential proteolytic cleavages that culminate in intramembrane cleavage and release of the Notch2 intracellular domain (NICD2). The cleaved intracellular domain translocates to the nucleus, where it associates with the DNA-binding protein RBPJ and transcriptional co-activators to drive expression of target genes, including members of the HES and HEY families. Detection of NOTCH2 cleaved at Asp1733 is widely used as a marker of active Notch2 signaling in developmental biology, stem cell regulation, immunology, and cancer research.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: membrane bound receptor; Motch B; Neurogenic locus notch homolog protein 2; Notch 2; Notch gene homolog 2; Notch homolog 2; putative cell-fate determining protein; transmembrane protein; unnamed protein product
基因别名: AGS2; AI853703; HJCYS; hN2; N2; NOTCH2
UniProt ID: (Human) Q04721, (Mouse) O35516
Entrez Gene ID: (Human) 4853, (Mouse) 18129, (Rat) 29492
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
cell fate determination
liver development
placenta development
heart looping
morphogenesis of an epithelial sheet
marginal zone B cell differentiation
inflammatory response to antigenic stimulus
atrioventricular node development
pulmonary valve morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
humoral immune response
Notch signaling pathway
determination of left/right symmetry
nervous system development
axon guidance
cell proliferation
positive regulation of cell proliferation
organ morphogenesis
negative regulation of macromolecule biosynthetic process
negative regulation of gene expression
positive regulation of keratinocyte proliferation
hemopoiesis
cell differentiation
embryonic limb morphogenesis
BMP signaling pathway
positive regulation of BMP signaling pathway
multicellular organism growth
intracellular signal transduction
intrahepatic bile duct development
wound healing
defense response to bacterium
regulation of apoptotic process
myeloid dendritic cell differentiation
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of Ras protein signal transduction
bone remodeling
regulation of developmental process
positive regulation of smooth muscle cell differentiation
cardiac septum morphogenesis
atrial septum morphogenesis
placenta blood vessel development
ciliary body morphogenesis
positive regulation of ERK1 and ERK2 cascade
left/right axis specification
cellular response to tumor cell
proximal tubule development
glomerular visceral epithelial cell development
glomerular capillary formation
hepatocyte proliferation
liver morphogenesis
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
regulation of hemopoiesis
cholangiocyte proliferation
regulation of osteoclast development
transcription, DNA-templated
cell cycle arrest
multicellular organism development
negative regulation of cell proliferation
cell growth
interleukin-4 secretion
tissue regeneration
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