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Invitrogen
NOTCH4 Polyclonal Antibody
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NOTCH4 Antibody (PA5-115664) in IHC (P)
Immunohistochemistry analysis of NOTCH4 in mouse lung tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115664) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115664
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NOTCH4(Accession Q99466), corresponding to amino acid residues R1474-G1524.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total NOTCH4.
靶标信息
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases (entrez gene).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAQB-143M3.4; FLJ16302; hNotch4; MGC74442; Neurogenic locus notch homolog protein 4; Notch 4; Notch gene homolog 4; NOTCH3
基因别名: Int-3; INT3; N4; NOTCH4
UniProt ID: (Mouse) P31695
Entrez Gene ID: (Rat) 406162, (Mouse) 18132
patterning of blood vessels
morphogenesis of a branching structure
endothelial cell morphogenesis
Notch signaling pathway
mammary gland development
endothelial cell differentiation
negative regulation of endothelial cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
regulation of Notch signaling pathway
embryo development
cell differentiation
regulation of protein localization
negative regulation of Notch signaling pathway
positive regulation of angiogenesis
regulation of protein processing
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