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Invitrogen
NOTUM Polyclonal Antibody
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NOTUM Antibody (PA5-95811) in WB
Western blot analysis of NOTUM in extracts of various cell lines. Samples were incubated with NOTUM Polyclonal antibody (Product # PA5-95811) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
产品信息
PA5-95811
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human NOTUM (NP_8485883)
偶联物
形式
Liquid
浓度
1.23 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SEGRKTWRRR GQQPPPPPRT EAAPAAGQPV ESFPLDFTAV EGNMDSFMAQ VKSLAQSLYP CSAQQLNEDL RLHLLLNTSV TCNDGSPAGY YLKESRGSRR WLLFLEGGWY CFNRENCDSR YDTMRRLMSS RDWPRTRTGT GILSSQPEEN PYWWNANMVF IPYCSSDVWS GASSKSEKNE YAFMGALIIQ EVVRELLGRG LSGAKVLLLA GSSAGGTGVL LNVDRVAEQL EKLGYPAIQV RGLADSGWFL DNKQYRHTDC VDTITCAPTE AIRRGIRYWN GVVPERCRRQ FQEGEEWNCF F; Positive Samples: BxPC-3, HepG2
靶标信息
Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the a/beta-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: [Wnt protein] O-palmitoleoyl-L-serine hydrolase; hNOTUM; notum pectinacetylesterase homolog; Palmitoleoyl-protein carboxylesterase NOTUM; protein notum homolog
基因别名: hNOTUM; NOTUM; OK/SW-CL.30
UniProt ID: (Human) Q6P988
Entrez Gene ID: (Human) 147111
