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Invitrogen
NOX4 Recombinant Rabbit Monoclonal Antibody (K01_4U39)
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产品信息
MA567808
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_4U39
抗原
A synthesized peptide derived from human NOX4.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 50% glycerol, 0.05% BSA, 150mM NaCl
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX-1; KOX1; NADPH oxidase 4; NOX 4; NOX-4; NOX4; NOX4v; Renal NAD(P)H-oxidase; Superoxide-generating NADPH oxidase 4; unnamed protein product
基因别名: AI648021; KOX; KOX-1; NOX4; RENOX
UniProt ID: (Human) Q9NPH5, (Rat) Q924V1, (Mouse) Q9JHI8
Entrez Gene ID: (Human) 50507, (Rat) 85431, (Mouse) 50490
nucleotide binding
protein binding
electron carrier activity
NAD(P)H oxidase activity
superoxide-generating NADPH oxidase activity
oxidoreductase activity
oxygen sensor activity
heme binding
flavin adenine dinucleotide binding
modified amino acid binding
superoxide-generating NADPH oxidase activity
protein tyrosine kinase binding
oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
oxidase
cell morphogenesis
heart process
superoxide metabolic process
defense response
inflammatory response
negative regulation of cell proliferation
gene expression
intracellular signal transduction
superoxide anion generation
bone resorption
homocysteine metabolic process
positive regulation of protein kinase B signaling
cardiac muscle cell differentiation
positive regulation of ERK1 and ERK2 cascade
cellular response to glucose stimulus
reactive oxygen species metabolic process
reactive oxygen species biosynthetic process
positive regulation of DNA biosynthetic process
response to hypoxia
aging
cell aging
positive regulation of smooth muscle cell migration
positive regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of stress fiber assembly
oxidation-reduction process
cellular response to cAMP
cellular response to gamma radiation
cellular response to transforming growth factor beta stimulus
positive regulation of reactive oxygen species metabolic process
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