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Invitrogen
NPR1 Polyclonal Antibody
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产品信息
PA5151094
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.4 mg/mL
规格
40 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Highest antigen sequence identity to the following orthologs: Mouse- 86%, Rat- 84%.
Sequence of this protein is as follows: FHLDIFGQSL QGGQGPAPRR PWERGDGQDV SARQAFQAAK IITYKDPDNP EYLEFLKQLK HLAYEQFNFT MEDGLVNTIP ASFHDGLLLY IQAVTETLAH GGTVTDGENI TQRMWNRSFQ GVTGYLKIDS SGDRETDFSL WDMDPENG
靶标信息
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms. The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A and type B. Also see NPR3, which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides and BNP, respectively).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ANP-A; ANPR-A; ARABIDOPSIS NONEXPRESSER OF PR GENES 1; AT1G64280; ATNPR1; Atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor guanylate cyclase; Atrial natriuretic peptide receptor type A; atrionatriuretic peptide receptor A; F15H21.6; F15H21_6; GC-A; Guanylate cyclase A; natriuretic peptide A type receptor; natriuretic peptide receptor A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); NIM1; NON-INDUCIBLE IMMUNITY 1; NONEXPRESSER OF PR GENES 1; NPR-A; REGULATORY PROTEIN NPR1; SAI1; SALICYLIC ACID INSENSITIVE 1; testicular tissue protein Li 20; unnamed protein product
基因别名: ANPa; ANPRA; GUC2A; GUCY2A; NPR1; NPRA
UniProt ID: (Human) P16066
Entrez Gene ID: (Human) 4881
cGMP biosynthetic process
cell surface receptor signaling pathway
receptor guanylyl cyclase signaling pathway
G-protein coupled receptor signaling pathway
body fluid secretion
blood circulation
regulation of blood pressure
cyclic nucleotide biosynthetic process
positive regulation of cGMP-mediated signaling
negative regulation of angiogenesis
cGMP-mediated signaling
negative regulation of cell growth
intracellular signal transduction
positive regulation of urine volume
positive regulation of renal sodium excretion
dopamine metabolic process
regulation of vascular permeability
negative regulation of smooth muscle cell proliferation
regulation of blood vessel diameter
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