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Invitrogen
NR0B1 Polyclonal Antibody
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产品信息
PA5-68576
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the C-terminal region of mouse NR0B1
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This target displays homology in the following species: Cow: 92%; Dog: 75%; Guinea Pig: 92%; Horse: 83%; Human: 100%; Mouse: 92%; Rabbit: 92%; Rat: 92%
靶标信息
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adrenal hypoplasia congenita-like protein; adrenal hypoplasia, congenital homolog; DAX 1; mDax1- 190; mDax1- 202; mDax1- 278; mDax1- 331; nuclear receptor DAX-1; R0B1; unnamed protein product
基因别名: Ahc; Ahch; AHX; DAX-1; Dax1; mDax1-134; mDax1-218; mDax1-225; mDax1-249; mDax1-292; mDax1-297; mDax1-300; mDax1-308; mDax1-318; mDax1-329; mDax1-337; mDax1-344; mDax1-38; mDax1-404; mDax1-472
UniProt ID: (Mouse) Q61066
Entrez Gene ID: (Mouse) 11614
nucleic acid binding
double-stranded DNA binding
transcription corepressor activity
RNA binding
protein binding
transcription factor binding
ligand-dependent nuclear receptor binding
protein domain specific binding
DNA hairpin binding
protein homodimerization activity
sequence-specific DNA binding
AF-2 domain binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
developmental process involved in reproduction
spermatogenesis
sex determination
protein localization
gonad development
male gonad development
negative regulation of steroid biosynthetic process
cell differentiation
male sex determination
adrenal gland development
negative regulation of intracellular steroid hormone receptor signaling pathway
Leydig cell differentiation
response to immobilization stress
negative regulation of gluconeogenesis
negative regulation of transcription, DNA-templated
Sertoli cell differentiation
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