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Invitrogen
NR0B1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-76024
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human NR0B1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adrenal hypoplasia congenita-like protein; adrenal hypoplasia, congenital homolog; DAX 1; DSS-AHC critical region on the X chromosome protein 1; mDax1- 190; mDax1- 202; mDax1- 278; mDax1- 331; nuclear hormone receptor; nuclear hormone receptor/negative regulator of retinoic acid receptor-mediated transcription; nuclear receptor DAX-1; R0B1; unnamed protein product
基因别名: AHC; AHCH; AHX; DAX-1; DAX1; DSS; GTD; HHG; mDax1-134; mDax1-218; mDax1-225; mDax1-249; mDax1-292; mDax1-297; mDax1-300; mDax1-308; mDax1-318; mDax1-329; mDax1-337; mDax1-344; mDax1-38; mDax1-404; mDax1-472; NROB1; SRXY2
UniProt ID: (Human) P51843, (Mouse) Q61066
Entrez Gene ID: (Human) 190, (Mouse) 11614
nucleic acid binding
transcription corepressor activity
RNA binding
protein binding
ligand-dependent nuclear receptor binding
protein domain specific binding
DNA hairpin binding
protein homodimerization activity
AF-2 domain binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
double-stranded DNA binding
transcription factor binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
developmental process involved in reproduction
spermatogenesis
sex determination
protein localization
gonad development
male gonad development
negative regulation of steroid biosynthetic process
cell differentiation
male sex determination
adrenal gland development
negative regulation of intracellular steroid hormone receptor signaling pathway
Leydig cell differentiation
response to immobilization stress
negative regulation of gluconeogenesis
negative regulation of transcription, DNA-templated
Sertoli cell differentiation
hypothalamus development
pituitary gland development
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