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Abnova
NR1H3 Monoclonal Antibody (3E9)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00010062-M08
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3E9
抗原
NR1H3 (AAH08819, 1 a.a. approximately 387 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: MSLWLGAPVP DIPPDSAVEL WKPGAQDASS QAQGGSSCIL REEARMPHSA GGTAGVGLEA AEPTALLTRA EPPSEPTEIR PQKRKKGPAP KMLGNELCSV CGDKASGFHY NVLSCEGCKG FFRRSVIKGA HYICHSGGHC PMDTYMRRKC QECRLRKCRQ AGMREECVLS EEQIRLKKLK RQEEEQAHAT SLPPRASSPP QILPQLSPEQ LGMIEKLVAA QQQCNRRSFS DRLRVTVMLL ETSRRYNPGS ESITFLKDFS YNREDFAKAG LQVEFINPIF EFSRAMNELQ LNDAEFALLI AISIFSADRP NVQDQLQVER LQHTYVEALH AYVSIHHPHD RLMFPRMLMK LVSLRTLSSV HSEQVFALRL QDKKLPPLLS EIWDVHE
靶标信息
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: LXRb; NER; NERI; NR1H2; unnamed protein product
基因别名: LXR-a; LXRA; RLD-1
UniProt ID: (Human) Q13133
Entrez Gene ID: (Human) 10062
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
cholesterol binding
chromatin DNA binding
sterol response element binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
lipid metabolic process
hormone-mediated signaling pathway
negative regulation of macrophage derived foam cell differentiation
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol efflux
regulation of lipid storage
negative regulation of cholesterol storage
cell differentiation
intracellular receptor signaling pathway
negative regulation of lipid transport
positive regulation of cholesterol transport
response to progesterone
positive regulation of toll-like receptor 4 signaling pathway
phosphatidylcholine acyl-chain remodeling
cholesterol homeostasis
regulation of circadian rhythm
mRNA transcription from RNA polymerase II promoter
negative regulation of macrophage activation
apoptotic cell clearance
positive regulation of fatty acid biosynthetic process
negative regulation of proteolysis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of lipid biosynthetic process
negative regulation of pinocytosis
negative regulation of inflammatory response
lipid homeostasis
sterol homeostasis
negative regulation of interferon-gamma-mediated signaling pathway
triglyceride homeostasis
cellular response to lipopolysaccharide
negative regulation of pancreatic juice secretion
negative regulation of secretion of lysosomal enzymes
negative regulation of cold-induced thermogenesis
negative regulation of response to endoplasmic reticulum stress
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