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Invitrogen
NR5A2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-110041
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 300-541 of human NR5A2 (NP_9955821)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.81 mg/mL
规格
181 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SIPHLILELL KCEPDEPQVQ AKIMAYLQQE QANRSKHEKL STFGLMCKMA DQTLFSIVEW ARSSIFFREL KVDDQMKLLQ NCWSELLILD HIYRQVVHGK EGSIFLVTGQ QVDYSIIASQ AGATLNNLMS HAQELVAKLR SLQFDQREFV CLKFLVLFSL DVKNLENFQL VEGVQEQVNA ALLDYTMCNY PQQTEKFGQL LLRLPEIRAI SMQAEEYLYY KHLNGDVPYN NLLIEMLHAK RA
靶标信息
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; CYP7A promoter-binding factor; fetoprotein transcription factor; fetoprotein-alpha 1 (AFP) transcription factor; FTF; FTF; similar to nuclear hormone receptor; FTZ F1; FTZ F1beta; FTZ-F1 beta; FTZ-F1 beta2 protein; hB1F 2; hepatocytic transcription factor hB1F-3; live; liver receptor homolog 1; nuclear receptor; nuclear receptor; similar to FTZ-F1; ORF; orphan nuclear receptor; unnamed protein product
基因别名: B1F; B1F2; CPF; D1Ertd308e; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1; mFTF; UF2-H3B
UniProt ID: (Human) O00482, (Mouse) P45448, (Rat) Q9QWM1
Entrez Gene ID: (Human) 2494, (Mouse) 26424, (Rat) 60349
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
phospholipid binding
zinc ion binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
primary ovarian follicle growth
inner cell mass cell differentiation
positive regulation of T cell anergy
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
bile acid metabolic process
male gonad development
hormone-mediated signaling pathway
tissue development
neurogenesis
intracellular receptor signaling pathway
epithelial cell differentiation
exocrine pancreas development
positive regulation of glucocorticoid biosynthetic process
negative regulation of chondrocyte differentiation
somatic stem cell population maintenance
embryonic cleavage
positive regulation of T cell proliferation
regulation of cell proliferation
cholesterol homeostasis
positive regulation of viral genome replication
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of inflammatory response
positive regulation of T cell activation
cartilage development
Sertoli cell development
pancreas morphogenesis
calcineurin-mediated signaling
morula formation
zygotic genome activation
cellular response to leukemia inhibitory factor
positive regulation of stem cell differentiation
positive regulation of tendon cell differentiation
embryo development ending in birth or egg hatching
homeostatic process
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