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Invitrogen
NRCAM Monoclonal Antibody (7D8C5)
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NRCAM Antibody (MA5-31810) in ICC/IF
Immunocytochemistry analysis of NRCAM in HepG2 cells (green). Sample was incubated with NRCAM monoclonal antibody (Product # MA5-31810) using a dilution of 1:50 followed by DRAQ5 fluorescent DNA dye (blue), and Alexa Fluor- 555 phalloidin (red labeled actin filaments) .
产品信息
MA5-31810
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
7D8C5
抗原
Purified recombinant fragment of human NRCAM (AA: 1192-1255) expressed in E. coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-31810 has been tested in indirect ELISA.
靶标信息
Neuron-glia-related cell adhesion molecule (NRCAM) is a gene located on chromosome 7q31.1, encoding a protein that belongs to the immunoglobulin superfamily of cell adhesion molecules. NRCAM is expressed in the nervous system and plays a vital role in the development and maintenance of neural connections. This adhesion molecule facilitates neuron-neuron and neuron-glia interactions, impacting processes such as axon guidance, synapse formation, and cell signaling, which are crucial for neural development and plasticity. NRCAM is involved in the modulation of signal transduction pathways that influence neuronal growth and repair, contributing to the stabilization of synaptic structures. Alterations in NRCAM expression or function have been linked to neurodevelopmental disorders, including autism spectrum disorders, and certain psychiatric conditions, reflecting its importance in maintaining neural circuit integrity. Research into NRCAM continues to explore its therapeutic potential in neurobiology and its implications in neurological and psychiatric disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hBravo; MGC138845; MGC138846; Neuronal cell adhesion molecule; Neuronal surface protein Bravo; Ng-CAM-related; NgCAM-related cell adhesion molecule; Nr CAM; Nr-CAM
基因别名: KIAA0343; NRCAM
UniProt ID: (Human) Q92823
Entrez Gene ID: (Human) 4897
angiogenesis
neuron migration
axonogenesis
axonal fasciculation
synapse assembly
central nervous system development
protein localization
single organismal cell-cell adhesion
neuronal action potential propagation
regulation of axon extension
retinal ganglion cell axon guidance
heterotypic cell-cell adhesion
clustering of voltage-gated sodium channels
positive regulation of neuron differentiation
