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Invitrogen
NRF1 Polyclonal Antibody
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Product Details
PA5-99445
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NRF1(Accession Q16656), corresponding to amino acid residues P222-Q272.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NRF1.
Target Information
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha palindromic-binding protein; Alpha-pal; EWG; NRF-1; Nuclear respiratory factor 1; nuclear respiratory factor-1
Gene Aliases: ALPHA-PAL; C87038; D6Ertd415e; Nfe2l1_retired; NRF1
UniProt ID: (Human) Q16656, (Mouse) Q9WU00
Entrez Gene ID: (Human) 4899, (Rat) 312195, (Mouse) 18181
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
protein homodimerization activity
molecular_function
DNA binding
transcription factor activity, sequence-specific DNA binding
DNA-binding transcription factor
response to hypoxia
generation of precursor metabolites and energy
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
mitochondrion organization
organ regeneration
response to estradiol
response to lipopolysaccharide
positive regulation of transcription from RNA polymerase II promoter
response to folic acid
response to electrical stimulus
transcription, DNA-templated
regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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