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Invitrogen
NRG1 Polyclonal Antibody
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NRG1 Antibody (PA5-34648) in ICC/IF
Immunofluorescence analysis of Pro-neuregulin-1, membrane-bound isoform was performed using 70% confluent log phase MDA-MB-231 cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with NRG1 Polyclonal Antibody (Product # PA5-34648) at 5 µg/mL in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Ale... View More
产品信息
PA5-34648
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the Extracellular domain of human Neuregulin-1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.96 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: Human brain, Mouse brain, rat brain.
Predicted reactivity: Rat (97%), Bovine (91%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acetylcholine receptor-inducing activity; glial growth factor 2; heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1 type III beta 3; NRG-1; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; type I neuregulin 1; type III neuregulin 1
基因别名: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGF2; GGFII; HGL; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF
UniProt ID: (Human) Q02297
Entrez Gene ID: (Human) 3084, (Rat) 112400, (Mouse) 211323
transcription cofactor activity
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
cytokine activity
ErbB-2 class receptor binding
integrin binding
growth factor activity
transmembrane receptor protein tyrosine kinase activator activity
receptor tyrosine kinase binding
ErbB-3 class receptor binding
chemorepellent activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
receptor binding
protein tyrosine kinase activator activity
growth factor
MAPK cascade
activation of MAPK activity
cell morphogenesis
startle response
cardiac conduction system development
ventricular trabecula myocardium morphogenesis
cell communication
activation of transmembrane receptor protein tyrosine kinase activity
nervous system development
synapse assembly
peripheral nervous system development
locomotory behavior
regulation of blood pressure
positive regulation of cell proliferation
embryo development
neural crest cell development
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
glucose transport
peptidyl-tyrosine phosphorylation
glial cell fate commitment
chemorepulsion involved in interneuron migration from the subpallium to the cortex
mammary gland development
positive regulation of myelination
activation of protein kinase B activity
intracellular signal transduction
ERBB signaling pathway
ERBB2 signaling pathway
wound healing
negative regulation of protein catabolic process
myelination
regulation of protein homodimerization activity
regulation of protein heterodimerization activity
positive regulation of GTPase activity
neurotransmitter receptor metabolic process
positive regulation of axon extension
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of Ras protein signal transduction
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
neuron fate commitment
oligodendrocyte differentiation
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of secretion
positive regulation of striated muscle cell differentiation
positive regulation of protein kinase B signaling
cardiac muscle cell differentiation
cardiac muscle cell myoblast differentiation
endocardial cell differentiation
positive regulation of dendritic spine development
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of protein targeting to mitochondrion
positive regulation of protein localization to cell surface
regulation of cell motility
positive regulation of cardiac muscle cell differentiation
negative regulation of neuron migration
transmembrane receptor protein tyrosine kinase signaling pathway
heart development
muscle organ development
cell proliferation
glial cell differentiation
negative regulation of cardiac muscle cell apoptotic process
cell migration
cell differentiation
positive regulation of cell growth
cellular protein complex disassembly
regulation of cell differentiation
positive regulation of cell adhesion
positive regulation of protein kinase activity
animal organ development
ventricular cardiac muscle cell differentiation
positive regulation of cardiac muscle cell proliferation
positive regulation of protein tyrosine kinase activity
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
axon ensheathment
