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Invitrogen
NRG3 Polyclonal Antibody
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Product Details
PA5-18552
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (RNEIQRDSALTK) corresponding to the C-terminus amino acids of NRG3 (aa 709-720).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with canine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3. NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HGNC:7999; neuregulin 3; neuregulin 3 variant 1; neuregulin 3 variant 10; neuregulin 3 variant 11; neuregulin 3 variant 12; neuregulin 3 variant 13; neuregulin 3 variant 14; neuregulin 3 variant 3; neuregulin 3 variant 4; neuregulin 3 variant 5; neuregulin 3 variant 6; neuregulin 3 variant 7; neuregulin 3 variant 8; neuregulin 3 variant 9; neuregulin-3-like polypeptide; Pro-neuregulin-3, membrane-bound isoform; Pro-NRG3; scaramanga
Gene Aliases: HRG3; NRG3; pro-NRG3; RGD1559678; ska
UniProt ID: (Human) P56975, (Mouse) O35181
Entrez Gene ID: (Human) 10718, (Rat) 498596, (Mouse) 18183
regulation of cell growth
activation of transmembrane receptor protein tyrosine kinase activity
pattern specification process
chemorepulsion involved in interneuron migration from the subpallium to the cortex
intracellular signal transduction
animal organ development
mammary placode formation
negative regulation of neuron migration
biological_process
mammary gland development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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