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Invitrogen
NRG4 Polyclonal Antibody
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产品信息
PA5-50341
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Fusion protein corresponding to residues near the N terminal of human neuregulin 4
偶联物
形式
Liquid
浓度
2.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody detects endogenous levels of total NRG4 protein.
靶标信息
Neuregulin 4 (NRG4) is a member of the Neuregulin family serving as a ligand for the epidermal growth factor receptor (EGFR) family, specifically interacting with ERBB4. This gene is primarily expressed in brown adipose tissue and liver, where it plays a pivotal role in metabolic regulation. NRG4 acts as a critical signaling molecule in adipose tissue, promoting systemic glucose homeostasis and energy expenditure while inhibiting hepatic lipogenesis, thereby contributing to protection against diet-induced obesity and insulin resistance. Moreover, NRG4 expression is inversely correlated with adiposity and positively correlated with insulin sensitivity, suggesting its potential role in metabolic homeostasis. Studies reveal that NRG4's interaction with ERBB4 stimulates specific cellular pathways, which can impact hepatic gluconeogenesis, underscoring its importance in glucose metabolism. Additionally, NRG4 has been linked to breast cancer progression, where it contributes to tumor cell survival through signaling pathways involving receptor tyrosine kinases. Due to its significant involvement in metabolic pathways and cancer biology, NRG4 is considered a promising target for therapeutic intervention in metabolic disorders and certain cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: heregulin 4; Pro-neuregulin-4, membrane-bound isoform; Pro-NRG4
基因别名: HRG4; NRG4
UniProt ID: (Human) Q8WWG1
Entrez Gene ID: (Human) 145957
MAPK cascade
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
intracellular signal transduction
ERBB2 signaling pathway
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
animal organ development
regulation of cell motility
