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Invitrogen
NSMCE1 Polyclonal Antibody
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NSMCE1 Antibody (PA5-90865) in WB
Western blot analysis of NSMCE1 in extracts of various cell lines. Samples were incubated with NSMCE1 Polyclonal antibody (Product # PA5-90865) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-90865
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 7-266 of human NSMCE1 (NP_6595472)
偶联物
形式
Liquid
浓度
4.03 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: RMGVMTDVHR RFLQLLMTHG VLEEWDVKRL QTHCYKVHDR NATVDKLEDF INNINSVLES LYIEIKRGVT EDDGRPIYAL VNLATTSISK MATDFAENEL DLFRKALELI IDSETGFASS TNILNLVDQL KGKKMRKKEA EQVLQKFVQN KWLIEKEGEF TLHGRAILEM EQYIRETYPD AVKICNICHS LLIQGQSCET CGIRMHLPCV AKYFQSNAEP RCPHCNDYWP HEIPKVFDPE KERESGVLKS NKKSLRSRQH; Positive Samples: BxPC-3, Rat testis; Cellular Location: Chromosome, Nucleus, telomere
靶标信息
The NSMCE1 (Non-SMC Element 1 Homolog) gene encodes a protein that is a key component of the SMC5-SMC6 complex, which is essential for DNA repair and the maintenance of genomic stability. Located on chromosome 16, the NSMCE1 protein interacts with other components of the SMC5-SMC6 complex, including SMC5, SMC6, and NSMCE2, facilitating the repair of DNA double-strand breaks and promoting chromosome segregation during cell division. NSMCE1 is particularly involved in homologous recombination, a critical pathway for error-free DNA repair. Mutations or deficiencies in NSMCE1 can lead to genomic instability, increased sensitivity to DNA-damaging agents, and have been associated with several genetic disorders and cancer predispositions.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Non-SMC element 1 homolog; Non-structural maintenance of chromosomes element 1 homolog
基因别名: HSPC333; HSPC337; NSE1; NSMCE1; RGD1307760
UniProt ID: (Human) Q8WV22, (Rat) Q499U6
Entrez Gene ID: (Human) 197370, (Rat) 361645
