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Invitrogen
NSMCE1 Monoclonal Antibody (K56018_3A9)
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NSMCE1 Antibody (MA5-55900) in IHC (P)
Immunohistochemistry analysis of NSMCE1 in paraffin-embedded testis tissue. Sample was incubated with NSMCE1 monoclonal antibody (Product # MA5-55900) at a dilution of 5 µg/mL (RT, 1 hour). Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endogenous peroxidase activity was quenched by incubating the sections with 3% H2O2 for 30 min at room temperature. ... View More
产品信息
MA5-55900
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
K56018_3A9
抗原
Recombinant human NSMCE1 (immunogen range is 1-266).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Sequence of this protein is as follows: MQGSTRRMGV MTDVHRRFLQ LLMTHGVLEE WDVKRLQTHC YKVHDRNATV DKLEDFINNI NSVLESLYIE IKRGVTEDDG RPIYALVNLA TTSISKMATD FAENELDLFR KALELIIDSE TGFASSTNIL NLVDQLKGKK MRKKEAEQVL QKFVQNKWLI EKEGEFTLHG RAILEMEQYI RETYPDAVKI CNICHSLLIQ GQSCETCGIR MHLPCVAKYF QSNAEPRCPH CNDYWPHEIP KVFDPEKERE SGVLKSNKKS LRSRQH
靶标信息
The NSMCE1 (Non-SMC Element 1 Homolog) gene encodes a protein that is a key component of the SMC5-SMC6 complex, which is essential for DNA repair and the maintenance of genomic stability. Located on chromosome 16, the NSMCE1 protein interacts with other components of the SMC5-SMC6 complex, including SMC5, SMC6, and NSMCE2, facilitating the repair of DNA double-strand breaks and promoting chromosome segregation during cell division. NSMCE1 is particularly involved in homologous recombination, a critical pathway for error-free DNA repair. Mutations or deficiencies in NSMCE1 can lead to genomic instability, increased sensitivity to DNA-damaging agents, and have been associated with several genetic disorders and cancer predispositions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Non-SMC element 1 homolog; Non-structural maintenance of chromosomes element 1 homolog
基因别名: HSPC333; HSPC337; NSE1; NSMCE1
UniProt ID: (Human) Q8WV22
Entrez Gene ID: (Human) 197370
