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This antibody recognizes N-terminal cytoplasmic domain of mouse Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.
Western Blot: non-reducing conditions.
NTAL (Non-T cell Activation Linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Linker for activation of B-cells; Linker for activation of T-cells family member 2; Membrane-associated adapter molecule; non-T cell activation linker; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein homolog; Williams-Beuren syndrome chromosome region 5 homolog
基因别名: AW125574; LAB; Lat2; NTAL; Wbscr15; Wbscr5; WSCR5
UniProt ID: (Mouse) Q9JHL0
Entrez Gene ID: (Mouse) 56743