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Invitrogen
NTAL Monoclonal Antibody (NAP-07)
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NTAL Antibody (MA1-19329) in ICC/IF
Immunocytochemistry analysis of NTAL by confocal microscopy in THP-1 human acute monocytic leukemia cell line. The cells were permeabilized and immunostained using anti-NTAL (NAP-07; green) Monoclonal antibody (Product # MA1-19329). Nuclei are vizualized by propidium iodide (red).
产品信息
MA1-19329
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
NAP-07
抗原
Recombinant cytoplasmic domain (aa 91-243) of human NTAL
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody reacts with an intracellular epitope of Non-T cell activation linker (NTAL), also known as LAB (linker of activated B cells), a 25 - 30 kDa transmembrane adaptor protein associating with lipid raft components in the plasma membrane of B lymphocytes, NK cells and myeloid cells.
Western Blot: Incubation 60 min; non-reducing conditions, 12% separating SDS-PAGE gel.
靶标信息
NTAL (Non-T cell Activation Linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Linker for activation of B-cells; linker for activation of T cells family, member 2; linker for activation of T cells, transmembrane adaptor 2; Linker for activation of T-cells family member 2; Membrane-associated adapter molecule; non-T cell activation linker; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 15 protein homolog; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosome region 5 homolog
基因别名: AW125574; HSPC046; LAB; LAT2; NTAL; WBS15; WBSCR15; WBSCR5; WSCR5
UniProt ID: (Human) Q9GZY6, (Mouse) Q9JHL0
Entrez Gene ID: (Human) 7462, (Mouse) 56743
