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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
This antibody reacts with an intracellular epitope of Non-T cell activation linker (NTAL), also known as LAB (linker of activated B cells), a 25 - 30 kDa transmembrane adaptor protein associating with lipid raft components in the plasma membrane of B lymphocytes, NK cells and myeloid cells.
Western Blot: Incubation 60 min; non-reducing conditions, 12% separating SDS-PAGE gel.
NTAL (Non-T cell Activation Linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Linker for activation of B-cells; Linker for activation of T-cells family member 2; Membrane-associated adapter molecule; non-T cell activation linker; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 15 protein homolog; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosome region 5 homolog
基因别名: AW125574; HSPC046; LAB; LAT2; NTAL; WBS15; WBSCR15; WBSCR5; WSCR5
UniProt ID: (Mouse) Q9JHL0
Entrez Gene ID: (Mouse) 56743