Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
NTHL1 Recombinant Mouse Monoclonal Antibody (K29067_15H5)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 1
NTHL1 Antibody (MA564425) in IHC (P)
Immunohistochemistry (Paraffin) analysis of NTHL1 in formalin-fixed paraffin-embedded heart muscle tissue. Samples were incubated with NTHL1 recombinant monoclonal (Product # MA564425) using a dilution of 7 µg/mL at room temperature for 1 hr followed by Poly-peroxidase conjugated goat anti-mouse IgG. Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endo... View More
产品信息
MA564425
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K29067_15H5
抗原
Recombinant human NTHL1 (aa 51-120).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.09% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SHSPVKRPRK AQRLRVAYEG SDSEKGEGAE PLKVPVWEPQ DWQQQLVNIR AMRNKKDAPV DHLGTEHCYD
Highest antigen sequence identity to the following orthologs: Mouse - 72%, Pig - 70%, Cynomolgus monkey - 93%.
靶标信息
Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites.A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; DNA glycosylase/AP lyase; Endonuclease III-like protein 1; hNTH1; nth endonuclease III-like 1; NTHL 1; OCTS 3
基因别名: FAP3; hNTH1; NTH1; NTHL1; OCTS3
UniProt ID: (Human) P78549
Entrez Gene ID: (Human) 4913
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
double-stranded DNA binding
DNA-(apurinic or apyrimidinic site) lyase activity
endonuclease activity
protein binding
oxidized purine nucleobase lesion DNA N-glycosylase activity
DNA N-glycosylase activity
metal ion binding
4 iron, 4 sulfur cluster binding
DNA metabolism protein
DNA glycosylase
nucleic acid metabolism protein
