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Invitrogen
NUDT15 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-58614
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.3 mg/mL
规格
30 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EKENYHYVTI LMKGEVDVTH DSEPKNVEPE KNESWEWVPW EELPPLDQLF WGLRCLKEQG YDPFKEDLNH LVGYKGNHL
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.
靶标信息
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 8-oxo-dGTPase NUDT15; mutT homolog 2; nucleoside diphosphate-linked to another moiety X hydrolase 15; nudix (nucleoside diphosphate linked moiety X)-type motif 15; nudix-type motif 15; probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; probable 8-oxo-dGTP diphosphatase NUDT15; RP11-90M2.1; unnamed protein product
基因别名: MTH2; NUDT15D
UniProt ID: (Human) Q9NV35
Entrez Gene ID: (Human) 55270
protein binding
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
dGTP diphosphatase activity
8-oxo-dGDP phosphatase activity
nucleoside-triphosphate diphosphatase activity
isoprenoid diphosphate phosphatase activity
farnesyl diphosphatase activity
mitotic cell cycle
purine nucleotide catabolic process
dGTP catabolic process
response to stress
purine deoxyribonucleoside triphosphate catabolic process
xenobiotic catabolic process
DNA protection
nucleobase-containing small molecule metabolic process
regulation of proteasomal protein catabolic process
nucleoside phosphate catabolic process
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