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This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-107 is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP107 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP107 may be an important drug target in HIV treatment. Multiple isoforms of NUP107 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: nuclear pore complex; Nuclear pore protein nup107; Nucleoporin nup107
基因别名: nup107; SPBC428.01c; SPBC582.11c
UniProt ID: (Fission yeast) Q10331
Entrez Gene ID: (Fission yeast) 3361255
分子生物学功能: transporter