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This antibody can react specifically with the 23 kDa NY-ESO-1 protein. During development reactivity was confirmed with human SKMEL-37 melanoma cells.
NY-ESO-1, a member of the CT (cancer/testis) family, is a tumor specific shared antigen with distinctive immunogenicity. The molecular basis of T cell-mediated antitumor immunity has been elucidated by the identification of a number of tumor antigens recognized by CD8+ T cells. Among these antigens, NY-ESO-1 is of particular interest because both the cytotoxic T lymphocyte and antibody have been shown to react with this antigen. The NY-ESO-1 has been detected in normal testis and in a range of human tumor types. NY-ESO-1 reactivity in testis is restricted germ cells, particularly in the spermatogonia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Autoimmunogenic cancer/testis antigen NY-ESO-1; Cancer/testis antigen 1; cancer/testis antigen 1-A; Cancer/testis antigen 6.1; CT6.1; L antigen family member 2; LAGE-2; New York Esophageal Squamous Cell Carcinoma 1
基因别名: CT6.1; CTAG; CTAG1; CTAG1A; CTAG1B; ESO1; LAGE-2; LAGE2; LAGE2A; LAGE2B; NY-ESO-1
UniProt ID: (Human) P78358
Entrez Gene ID: (Human) 246100