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Invitrogen
Natalizumab Chimeric Recombinant Rabbit Monoclonal Antibody (Natalizumab)
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Natalizumab Chimeric Antibody (MA5-48046) in Flow
Flow Cytometry analysis of Natalizumab in Human lymphocytes using Natalizumab Chimeric Monoclonal Antibody (Product # MA5-48046). Cells were stained with an isotype control, FITC Chimeric monoclonal antibody (Product # MA5-47752) (panel A), or Natalizumab Chimeric Monoclonal Antibody (panel B) at a concentration of 1 µg/mL for 30 mins at RT. After washing, bound antibody was detected using a AF488 conjugate... View More
产品信息
MA5-48046
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
Natalizumab
抗原
The RAMOS cell line, a non-EBV releasing cell line, injected into mice.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Specificity: This antibody binds to the alpha 4 binds subunit of alpha-4Beta1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and alpha-4Beta7 integrin
靶标信息
Natalizumab is a recombinant, humanized monoclonal antibody, binds to alpha4beta1-integrinand blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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