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Antibodies Inc
Navbeta1 Na+ Channel Monoclonal Antibody (N405/74)
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产品信息
75-425
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
N405/74
抗原
Fusion protein amino acids 14-160 (extracellular N-terminus) of rat Navbeta1 (accession number Q00954) produced recombinantly in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4
内含物
0.065% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Sodium channel regulatory subunit beta-1; sodium channel subunit beta-1; sodium channel voltage-gated type 1 beta polypeptide; sodium channel voltage-gated type I beta polypeptide; sodium channel, voltage-gated, type 1, beta polypeptide; sodium channel, voltage-gated, type I, beta polypeptide
基因别名: Scn1b
UniProt ID: (Mouse) P97952, (Rat) Q00954
Entrez Gene ID: (Mouse) 20266, (Rat) 29686
voltage-gated ion channel activity
voltage-gated sodium channel activity
sodium channel activity
protein binding
sodium channel regulator activity
sodium channel inhibitor activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
voltage-gated sodium channel activity involved in Purkinje myocyte action potential
ion channel
transporter
voltage-gated ion channel
regulation of sodium ion transport
transport
ion transport
sodium ion transport
axon guidance
positive regulation of sodium ion transport
positive regulation of neuron projection development
neuronal action potential propagation
corticospinal neuron axon guidance
regulation of ion transmembrane transport
sodium ion transmembrane transport
locomotion
response to pyrethroid
membrane depolarization
cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of atrial cardiac muscle cell membrane depolarization
cardiac conduction
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during Purkinje myocyte cell action potential
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transporter activity
