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Alomone Labs, LTD
Netrin-3 Polyclonal Antibody
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Netrin-3 Antibody (ANR-123-200UL) in IHC (F)
Expression of Netrin-3 in rat spinal cord. Immunohistochemical staining of perfusion-fixed frozen rat spinal cord sections with Anti-Netrin-3 Antibody (#ANR-123), (1:1000), followed by goat Anti-rabbit-AlexaFluor-488. A. Staining in the ventral horn region showed Netrin-3 immunoreactivity (green) in neuronal profiles (arrows). B. Pre-incubation of the Antibody with Netrin-3 Blocking Peptide (BLP-NR123), sup... View More
产品信息
ANR-123-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide CRPARGSYRISLKK, corresponding to amino acid residues 445-458 of mouse Netrin-3, Secreted
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Netrin-3 (NTN3) is a gene located on chromosome 16q22.1, encoding a protein that belongs to the netrin family of secreted molecules crucial for axon guidance and cell signaling in nervous system development. NTN3 is primarily expressed in the central nervous system, where it functions as a guidance cue for developing neurons, influencing processes such as axon attraction or repulsion and the establishment of neural networks. The protein interacts with specific receptors on neuronal growth cones to mediate directional movement and synapse formation. Beyond its role in neural development, NTN3 is involved in tissue morphogenesis and cellular migration in other physiological contexts. Aberrant expression or mutations in NTN3 can lead to developmental disorders and neurodegenerative conditions due to impaired neural pathway formation. Research into NTN3 continues to explore its therapeutic potential for enhancing neural repair and regeneration in pathological states.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Netrin-2, chicken, homolog of, like; Netrin-2-like protein; Netrin-3
基因别名: NTN2L; NTN3
UniProt ID: (Human) O00634, (Mouse) Q9R1A3
Entrez Gene ID: (Human) 4917, (Mouse) 18209, (Rat) 114524
