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Invitrogen
NeuGc-GM3 (Racotumomab Biosimilar) Recombinant Mouse Monoclonal Antibody
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NeuGc-GM3 (Racotumomab Biosimilar) Antibody (MA5-41827) in SDS-PAGE
SDS-PAGE analysis of the recombinant Human Idiotope of NeuGc-GM3 (Racotumomab Biosimilar) monoclonal antibody P3 protein expressed in CHO cells using a NeuGc-GM3 (Racotumomab Biosimilar) monoclonal antibody (Product # MA5-41827). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
产品信息
MA5-41827
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human Idiotope of anti-(N-glycolylneuraminic acid (NeuGc,NGNA) -gangliosides GM3) Mus musculus IgM-kappa monoclonal antibody P3
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.66 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
NeuGc-GM3 is a sialic acid-containing ganglioside in which the GM3 glycosphingolipid carries N-glycolylneuraminic acid (Neu5Gc) instead of the more common N-acetylneuraminic acid (Neu5Ac). While most normal human tissues lack Neu5Gc due to an inactive CMAH enzyme, NeuGc-GM3 is frequently detected in certain tumors, including melanoma, breast cancer, and lung cancer. Because of its limited expression in healthy human tissues and elevated presence in malignancies, NeuGc-GM3 is considered a tumor-associated antigen and has been investigated as a target for cancer immunotherapy and antibody-based treatments.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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