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Neuregulin-HBD (Heparin Binding Domain/Type I/II) Monoclonal Antibody (N120A/9), FL550

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Neuregulin-HBD (Heparin Binding Domain/Type I/II) Monoclonal Antibody (N120A/9), FL550

产品信息

75-225-FL550

应用
建议稀释比
已发表文章

免疫细胞化学 (ICC/IF)

Assay-dependent
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

N120A/9

抗原

Fusion protein amino acids 14-117 (extracellular N-terminus) of human Neuregulin-1 (accession number Q02297) produced recombinantly in E. Coli.
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偶联物

FL550 FL550 FL550

激发/发射光谱

550/575 nm

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Dry ice (international)

产品详细信息

For maximum recovery of product, centrifuge the vial prior to removing the cap.

靶标信息

Neuregulin-HBD refers to the heparin-binding domain (HBD) of neuregulins, a family of EGF-like signaling proteins involved in cell-cell communication. The heparin-binding domain is crucial for the interaction of neuregulins with heparan sulfate proteoglycans on the cell surface, which can modulate their signaling activity and influence processes such as cell growth, differentiation, and repair. Neuregulins and their HBDs play significant roles in the development and function of the nervous system, heart, and other tissues.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: acetylcholine receptor-inducing activity; glial growth factor 2; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor

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基因别名: ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF

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UniProt ID: (Human) Q02297

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Entrez Gene ID: (Human) 3084

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功能
transcription cofactor activity protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity cytokine activity ErbB-2 class receptor binding integrin binding growth factor activity transmembrane receptor protein tyrosine kinase activator activity receptor tyrosine kinase binding ErbB-3 class receptor binding chemorepellent activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity growth factor
参与通路
MAPK cascade activation of MAPK activity cell morphogenesis startle response cardiac conduction system development ventricular trabecula myocardium morphogenesis cell communication activation of transmembrane receptor protein tyrosine kinase activity nervous system development synapse assembly peripheral nervous system development locomotory behavior regulation of blood pressure positive regulation of cell proliferation embryo development neural crest cell development regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling glucose transport peptidyl-tyrosine phosphorylation glial cell fate commitment chemorepulsion involved in interneuron migration from the subpallium to the cortex mammary gland development positive regulation of myelination activation of protein kinase B activity intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway wound healing negative regulation of protein catabolic process myelination regulation of protein homodimerization activity regulation of protein heterodimerization activity positive regulation of GTPase activity neurotransmitter receptor metabolic process positive regulation of axon extension negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of Ras protein signal transduction phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling neuron fate commitment oligodendrocyte differentiation positive regulation of peptidyl-tyrosine phosphorylation negative regulation of secretion positive regulation of striated muscle cell differentiation positive regulation of protein kinase B signaling cardiac muscle cell differentiation cardiac muscle cell myoblast differentiation endocardial cell differentiation positive regulation of dendritic spine development positive regulation of calcineurin-NFAT signaling cascade positive regulation of protein targeting to mitochondrion positive regulation of protein localization to cell surface regulation of cell motility positive regulation of cardiac muscle cell differentiation negative regulation of neuron migration
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