Invitrogen

Neurexin-1-beta Polyclonal Antibody

Name: Neurexin-1-beta Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-71368

查看其他7个Neurexin-1-beta抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

PA5-71368

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1.0 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

synthetic peptide directed towards the C terminal region of human NRXN1

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2690795

靶标信息

Neurexin-1-beta (NRXN1-beta) is a gene that encodes the beta-isoform of the neurexin-1 protein, which is a type I membrane protein that functions as a cell adhesion molecule and receptor in the nervous system. Located on chromosome 2 in humans, the neurexin-1 gene undergoes complex alternative splicing, producing multiple isoforms, including the well-studied alpha-neurexin and beta-neurexin. Neurexins, including NRXN1-beta, are primarily involved in synapse formation and function by mediating interactions between presynaptic and postsynaptic neurons. They bind to neuroligins, another family of cell adhesion molecules, thus playing a critical role in the maintenance and regulation of synaptic specificity and neurotransmitter release. Dysregulation or mutations in NRXN1-beta have been implicated in various neurological and psychiatric disorders, including autism spectrum disorders, schizophrenia, and intellectual disabilities, emphasizing the importance of this gene in brain development and function.

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