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Invitrogen
NeuroD2 Polyclonal Antibody
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图: 1 / 4
NeuroD2 Antibody (PA5-104530) in ICC/IF
Immunocytochemistry analysis of NeuroD2 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with NeuroD2 polyclonal antibody (Product # PA5-104530) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-104530
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NEUROD2(Accession Q15784), corresponding to amino acid residues K74-Q124.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total NDF2.
靶标信息
Members of the myogenic determination family are basic helix-loop-helix (bHLH) proteins that can be separated into two classes, both of which work together to activate DNA transcription. Class A proteins include the ubiquitously expressed E-box binding factors, namely E2A, ITF-2 and HEB, while class B proteins, such as MyoD, myogenin and Neuro D (BETA2), are transiently expressed and exhibit a much more limited tissue distribution. Neuro D2 (neurogenic differentiation 2), also known as NDRF, NEUROD2 or bHLHa1, is a 382 amino acid nuclear protein that contains one bHLH domain and functions to induce neurogenic differentiation, playing an important role in the maintenance and determination of cell fate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHa1; Brain bHLH protein KW8; Class A basic helix-loop-helix protein 1; NDF2; NDR2; NDRF; NeuroD-related factor; NeuroD2; neurogenic basic-helix-loop-helix protein; neurogenic differentiation 2; Neurogenic differentiation factor 2
基因别名: BHLHA1; DEE72; EIEE72; NDRF; NEUROD2
UniProt ID: (Mouse) Q62414, (Rat) Q63689
Entrez Gene ID: (Human) 4761, (Mouse) 18013, (Rat) 54276
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein heterodimerization activity
protein dimerization activity
E-box binding
sequence-specific double-stranded DNA binding
transcription corepressor activity
protein binding
basic helix-loop-helix transcription factor
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
sensory organ development
protein ubiquitination
cerebellar cortex development
positive regulation of synaptic plasticity
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of calcium-mediated signaling
axon development
cellular response to electrical stimulus
cellular response to calcium ion
positive regulation of synapse maturation
negative regulation of synapse maturation
behavioral fear response
transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
associative learning
cell differentiation
neuron development
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of nucleic acid-templated transcription
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