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Invitrogen

Neuropilin-1 Recombinant Rabbit Monoclonal Antibody (0K1O1)

查看其他48个Neuropilin 1 (CD304)抗体

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说明书
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说明书
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实验方案
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说明书
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产品信息

MA575635

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:1500-1:6,000
-

免疫细胞化学 (ICC/IF)

1:200-1:800
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

0K1O1

抗原

Recombinant protein (or fragment).This information is considered to be commercially sensitive.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.49 mg/mL

规格

149 µg

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 0.05% BSA, 50% glycerol

内含物

0.09% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Neuropilin 1 is a 923 amino acid containing membrane bound coreceptor to a tyrosine kinase receptor belonging to the neuropilin family with two CUB domains, two F5/8 type C domains and a MAM domain. Neuropilin 1 forms a heterodimer with NRP2 (Neuropilin 2) and is known to bind to plexin (PLXNB1) to form semaphorin receptors. Expressed mostly in the nervous system this receptor is implicated in a wide range of functions including in the development of the cardiovascular system, angiogenesis, repulsive axon guidance, formation of certain neuronal circuits, cell survival, control of neuronal migration and organogenesis outside the nervous system. This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis. Neuropilin 1 may be involved in aggressive advanced prostate carcinoma and in the progression of breast cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: A5 protein; alternatively spliced; lacks exon 16; Neuropilin; Neuropilin-1 precursor (A5 protein); Neuropilin1; NRP 1; receptor for VEGF165 and semaphorins class 3; sNRP 1; sNRP1; soluble NRP 1; soluble NRP1; transmembrane receptor; type I transmembrane protein; unnamed protein product; vascular endothelial cell growth factor 165 receptor; VEGF 165 receptor

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基因别名: BDCA4; C530029I03; CD304; NP-1; NP1; NPN-1; Npn1; NRP; VEGF165R

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UniProt ID: (Human) O14786, (Rat) Q9QWJ9, (Mouse) P97333

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Entrez Gene ID: (Human) 8829, (Rat) 246331, (Mouse) 18186

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功能
vascular endothelial growth factor-activated receptor activity GTPase activator activity protein binding coreceptor activity semaphorin receptor activity growth factor binding protein kinase binding cytokine binding vascular endothelial growth factor binding
参与通路
angiogenesis patterning of blood vessels vasculogenesis neural crest cell migration neuron migration sprouting angiogenesis cell migration involved in sprouting angiogenesis outflow tract septum morphogenesis cardiac neural crest cell migration involved in outflow tract morphogenesis substrate-dependent cell migration, cell extension integrin-mediated signaling pathway nervous system development axon guidance axonal fasciculation heart development motor neuron axon guidance response to wounding positive regulation of endothelial cell migration positive regulation of platelet-derived growth factor receptor signaling pathway dendrite development cell migration facial nerve structural organization trigeminal nerve morphogenesis trigeminal nerve structural organization vestibulocochlear nerve structural organization branchiomotor neuron axon guidance gonadotrophin-releasing hormone neuronal migration to the hypothalamus positive regulation of cell migration negative regulation of axon extension regulation of vascular endothelial growth factor receptor signaling pathway retinal ganglion cell axon guidance regulation of Cdc42 protein signal transduction cellular response to hepatocyte growth factor stimulus endothelial cell chemotaxis cellular response to vascular endothelial growth factor stimulus ventral trunk neural crest cell migration vascular endothelial growth factor signaling pathway neuropilin signaling pathway VEGF-activated neuropilin signaling pathway wound healing positive regulation of phosphorylation negative regulation of neuron apoptotic process endothelial cell migration positive regulation of angiogenesis platelet-derived growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway hepatocyte growth factor receptor signaling pathway sympathetic nervous system development neuron development regulation of axon extension involved in axon guidance positive regulation of axon extension involved in axon guidance negative regulation of axon extension involved in axon guidance artery morphogenesis axon extension involved in axon guidance positive chemotaxis positive regulation of chemotaxis positive regulation of filopodium assembly positive regulation of stress fiber assembly positive regulation of focal adhesion assembly axonogenesis involved in innervation dichotomous subdivision of terminal units involved in salivary gland branching angiogenesis involved in coronary vascular morphogenesis coronary artery morphogenesis retina vasculature development in camera-type eye retina vasculature morphogenesis in camera-type eye renal artery morphogenesis sympathetic ganglion development trigeminal ganglion development positive regulation of ERK1 and ERK2 cascade semaphorin-plexin signaling pathway positive regulation of smooth muscle cell chemotaxis commissural neuron axon guidance positive regulation of cell migration involved in sprouting angiogenesis sensory neuron axon guidance motor neuron migration sympathetic neuron projection extension sympathetic neuron projection guidance postsynapse organization basal dendrite development basal dendrite arborization positive regulation of substrate adhesion-dependent cell spreading neural crest cell migration involved in autonomic nervous system development protein localization to early endosome facioacoustic ganglion development positive regulation of vascular associated smooth muscle cell migration dorsal root ganglion morphogenesis otic placode development negative regulation of extrinsic apoptotic signaling pathway viral entry into host cell cell migration involved in coronary vasculogenesis positive regulation of endothelial cell proliferation signal transduction cell-cell signaling organ morphogenesis positive regulation of smooth muscle cell migration regulation of vesicle-mediated transport endothelial tip cell fate specification regulation of plasma membrane bounded cell projection organization
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