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Alomone Labs, LTD
Neurotensin Receptor 2 Polyclonal Antibody
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Neurotensin Receptor 2 Antibody (ANT-016-200UL) in ICC/IF
Expression of NTR2 in rat C6 glioma cells - Immunocytochemical staining of rat C6 glioma cells. A. Paraformaldehyde fixed and permeabilized rat C6 glioma cells were stained with Anti-Neurotensin Receptor 2 Antibody (#ANT-016), (1:200), followed by Alexa-555 conjugated goat- Anti-rabbit- secondary Antibody (orange staining). Nuclei were visualized with the cell permeable dye Hoechst 33342 (blue staining). B.... View More
产品信息
ANT-016-200UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CGEQHSLVPLPQEAPE, corresponding to amino acid residues 377-392 of rat NTSR2, Intracellular, C-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: High-affinity levocabastine-sensitive neurotensin receptor; low affinity neurotensin receptor; Low-affinity levocabastine-sensitive neurotensin receptor; Neurotensin receptor type 2; NT-R-2; NT2 receptor; NTR2; NTR2 receptor; NTRL
基因别名: NT2R; Ntr2; NTRL; Ntsr2
UniProt ID: (Rat) Q63384, (Mouse) P70310
Entrez Gene ID: (Rat) 64636, (Mouse) 18217
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
regulation of membrane potential
positive regulation of MAPK cascade
positive regulation of ERK1 and ERK2 cascade
signal transduction
G-protein coupled receptor signaling pathway
