Invitrogen

Nhe-1 Polyclonal Antibody

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
技术支持
Nhe-1 Polyclonal Antibody

产品信息

PA5-80033

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL
-

免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

E.coli-derived human SLC9A1 recombinant protein (Position: H543-Q815).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5mg BSA

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2747148

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: rat PC-12 whole cell, human MCF-7 whole cell. IHC: rat kidney tissue, human mammary cancer tissue, mouse kidney tissue.

靶标信息

The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: APNH; Na(+)/H(+) antiporter, amiloride-sensitive; Na(+)/H(+) exchanger 1; Na+/H+ antiporter; Na+/H+, amiloride sensitive; Na-Li countertransporter; NHE-1; protein phosphatase 1, regulatory subunit 143; slow-wave epilepsy; Sodium/hydrogen exchanger 1; Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); Solute carrier family 9 member 1; solute carrier family 9, member 1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1

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基因别名: APNH; APNH1; AW554487; LIKNS; mir-5122; Mir5122; NHE-1; NHE1; PPP1R143; SLC9A1; swe

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UniProt ID: (Human) P19634, (Rat) P26431, (Mouse) Q61165

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Entrez Gene ID: (Human) 6548, (Rat) 24782, (Mouse) 20544

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功能
protein binding calmodulin binding phosphatidylinositol-4,5-bisphosphate binding solute:proton antiporter activity sodium:proton antiporter activity potassium:proton antiporter activity protein phosphatase 2B binding protein binding, bridging protein complex scaffold calcium-dependent protein binding sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential antiporter activity transporter secondary carrier transporter
参与通路
ion transport cellular sodium ion homeostasis regulation of pH response to acidic pH positive regulation of cardiac muscle hypertrophy regulation of cardiac muscle contraction by calcium ion signaling cell growth cell migration maintenance of cell polarity hyaluronan catabolic process positive regulation of cell growth cellular response to insulin stimulus positive regulation of mitochondrial membrane permeability response to muscle stretch response to drug positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of action potential positive regulation of transcription from RNA polymerase II promoter protein oligomerization regulation of intracellular pH regulation of stress fiber assembly positive regulation of NFAT protein import into nucleus regulation of focal adhesion assembly regulation of sensory perception of pain cardiac muscle cell differentiation positive regulation of calcineurin-NFAT signaling cascade neuron death cellular response to antibiotic cellular response to electrical stimulus cellular response to mechanical stimulus sodium ion export cellular response to hypoxia cellular response to acidic pH potassium ion transmembrane transport cellular response to epinephrine stimulus cardiac muscle cell contraction regulation of cardiac muscle cell membrane potential regulation of the force of heart contraction by cardiac conduction sodium ion import across plasma membrane positive regulation of the force of heart contraction hydrogen ion transmembrane transport positive regulation of calcium:sodium antiporter activity regulation of the force of heart contraction sodium ion transport response to organic cyclic compound cell differentiation sodium ion transmembrane transport cellular response to organic cyclic compound positive regulation of intracellular signal transduction transport cation transport embryo development transmembrane transport
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