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Invitrogen
Nimesulide Recombinant Mouse Monoclonal Antibody (1E2)
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Nimesulide Antibody (MA566400) in SDS-PAGE
SDS-PAGE characterization of Nimesulide under reducing conditions. Lane M: Protein marker (kDa); Lane NMS: Purified Nimesulide Recombinant Monoclonal (Product # MA566400). Nimesulide showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-677.
产品信息
MA566400
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1E2
抗原
Conjugate of NMS hapten and KLH.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
5.6 mg/mL
规格
200 µg
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) known for its analgesic and antipyretic properties, primarily acting as a selective cyclooxygenase-2 (COX-2) inhibitor. This specificity allows it to exert milder effects on the gastrointestinal mucosa compared to non-selective NSAIDs. Recent studies have explored its potential antitumor activity, leading to the development of new nimesulide derivatives with amide and sulfonamide moieties, which exhibit anti-inflammatory and anticancer effects. These derivatives have been synthesized and characterized using spectroscopic techniques, and their pharmacological profiles suggest multitarget capabilities, including the inhibition of tubulin and HSP27 functions, which are crucial in cancer treatment. The chemical structure of nimesulide and its derivatives continues to inspire research into their potential therapeutic applications beyond inflammation control.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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