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TTF-1 has been identified as a mediator of thyroid-specific gene transcription, and is involved in the activation of pulmonary-specific genes. TTF-1 is found in primary lung adenocarcinomas and small cell carcinomas. TTF-1 is usually absent in breast and colon carcinomas. TTF-1 monoclonal antibody should be useful in differentiating tumors of lung and non-lung origin. Lung cancer and thyroid gland tissues have been identified positive for TTF-1 monoclonal antibody concentrate.
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
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蛋白别名: Homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK-2 homolog A; T/EBP; Thyroid nuclear factor 1; Thyroid transcription factor 1; Thyroid-specific enhancer-binding protein; TTF-1; TTF1
基因别名: BCH; BHC; NK-2; NKX2-1; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1
UniProt ID: (Human) P43699
Entrez Gene ID: (Human) 7080