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Invitrogen
Nkx2.5 Polyclonal Antibody
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Nkx2.5 Antibody (PA5-23387) in IHC (P)
Immunohistochemical analysis of Nkx2.5 in formalin-fixed, paraffin-embedded human brain tissue. Samples were incubated in Nkx2.5 polyclonal antibody (Product # PA5-23387) using a dilution of 5 µg/mL. Isotype control (top left) and NBP2-24675 (bottom left, right).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-23387
产品规格
种属反应
Human,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 300-324 of human NKX2-5.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The amino acid sequence used as immunogen is 88% homologous in mouse, rat and opossum.
靶标信息
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cardiac-specific homeobox; cardiac-specific homeobox 1; FLJ52202; FLJ97166; FLJ97195; FLJ97197; FLJ99536; Homeobox protein CSX; Homeobox protein NK-2 homolog E; homeobox protein NKX 2-5; Homeobox protein Nkx-2.5; NK2 transcription factor related locus 5 (Drosophila) isoform NKX2-5_1; NK2 transcription factor related locus 5 (Drosophila) isoform NKX2-5_2; NK2 transcription factor related, locus 5; NKX 2-5; Nkx-2.5; Nkx-25; tinman homolog; tinman paralog; unnamed protein product
基因别名: CHNG5; CSX; CSX1; HLHS2; NKX2-5; NKX2.5; NKX2E; NKX4-1; VSD3
Entrez Gene ID: (Human) 1482
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
heart looping
heart morphogenesis
outflow tract septum morphogenesis
cardiac conduction system development
atrioventricular node development
bundle of His development
aortic valve morphogenesis
right ventricular cardiac muscle tissue morphogenesis
atrial cardiac muscle tissue development
septum secundum development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
adult heart development
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
positive regulation of sodium ion transport
negative regulation of myotube differentiation
hemopoiesis
cell differentiation
thyroid gland development
embryonic heart tube development
negative regulation of apoptotic process
positive regulation of neuron differentiation
positive regulation of heart contraction
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
spleen development
positive regulation of cardioblast differentiation
cardiac muscle cell differentiation
cardiac muscle tissue morphogenesis
cardiac muscle cell development
atrial cardiac muscle cell development
ventricular cardiac muscle cell development
regulation of cardiac muscle contraction
pharyngeal system development
positive regulation of transcription initiation from RNA polymerase II promoter
cardiac septum morphogenesis
ventricular septum morphogenesis
atrial septum morphogenesis
negative regulation of canonical Wnt signaling pathway
regulation of cardiac conduction
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