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Invitrogen
Nkx3.1 Monoclonal Antibody (738907)
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产品信息
MA5-61670
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
738907
抗原
E. coli-derived recombinant mouse NKX3.1, Met1-Pro124 (predicted)
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
靶标信息
The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Drosophila NK-3 transcription factor, locus 1; Homeobox protein NK-3 homolog A; Homeobox protein Nkx-3.1; NKX3-1 antibody; prostate-specific ag
基因别名: bagpipe; Bax; Nkx-3.1; Nkx3-1; NKX3.1; NKX3A
UniProt ID: (Mouse) P97436
Entrez Gene ID: (Mouse) 18095
transcription regulatory region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
core promoter binding
DNA binding
transcription factor activity, sequence-specific DNA binding
androgen receptor activity
protein binding
transcription factor binding
cysteine-type endopeptidase activator activity involved in apoptotic process
estrogen receptor activity
protein kinase activator activity
estrogen receptor binding
histone deacetylase binding
sequence-specific DNA binding
protein self-association
transcription regulatory region DNA binding
MADS box domain binding
homeodomain transcription factor
urogenital system development
positive regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
activation of cysteine-type endopeptidase activity involved in apoptotic process
multicellular organism development
salivary gland development
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell death
positive regulation of phosphatidylinositol 3-kinase signaling
androgen receptor signaling pathway
prostate gland development
response to testosterone
internal genitalia morphogenesis
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
steroid hormone mediated signaling pathway
protein kinase B signaling
negative regulation of insulin-like growth factor receptor signaling pathway
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
branching morphogenesis of an epithelial tube
negative regulation of epithelial cell proliferation
positive regulation of cell division
branching involved in prostate gland morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to steroid hormone stimulus
cellular response to hypoxia
mitotic cell cycle arrest
negative regulation of estrogen receptor binding
positive regulation of androgen secretion
positive regulation of response to DNA damage stimulus
positive regulation of apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
