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Invitrogen
Nofetumomab Recombinant Mouse Monoclonal Antibody
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Nofetumomab Antibody (MA5-41755) in SDS-PAGE
SDS-PAGE analysis of the recombinant Human IL3RA/CD123 protein expressed in CHO cells using a Nofetumomab biosimilar monoclonal antibody (Product # MA5-41755). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
产品信息
MA5-41755
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, F(ab), kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human CD20/MS4A1
偶联物
形式
Liquid
浓度
2.2 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Technetium Tc-99m nofetumomab merpentan (Tc-99m nm) consists of a Fab fragment of an IgG2b of the pancarcinoma murine antibody NR-LU-10. 1The NR-LU-10 antibody is directed against a 40 kDa glycoprotein antigen expressed in a variety of cancers and some normal tissues. LabelTc-99m nm was developed by Boehringer Ingelheim Pharma KG and FDA approved on September 14, 1992. It was after discontinued on August 13, 2013, but in the 2018 FDA submission list, it can be found as a substance type II (pharmaceutical substance) with an active status. The mechanism of action in Tc-99m nm is ruled by the presence of nofetumomab, which can recognize the pancarcinoma antigen EpCAM and/or CD20/MS4A1, 2and merpentan, that acts as a linker for the binding of technetium.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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