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Invitrogen
Nogo Recombinant Rabbit Monoclonal Antibody (K01_3W14)
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产品信息
MA567051
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_3W14
抗原
A synthesized peptide derived from human Nogo.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 50% glycerol, 0.05% BSA, 150mM NaCl
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Nogo, also known as RTN4, encodes a membrane protein that limits axon growth and regeneration in the central nervous system. The gene produces multiple isoforms (Nogo-A, Nogo-B, Nogo-C) via alternative promoters and splicing; Nogo-A is highly expressed in oligodendrocytes and is the principal inhibitor of neurite outgrowth. Nogo engages receptors including NgR1 (RTN4R), LINGO1, and p75 or TROY, activating RhoA/ROCK signaling that stabilizes growth cone collapse and restricts plasticity after injury. Beyond axon guidance, Nogo isoforms contribute to membrane dynamics, endoplasmic reticulum structure, vascular function, and immune signaling. Experimental blockade of Nogo or its receptor complex can enhance sprouting and functional recovery in animal models, making the pathway a target for therapies in spinal cord injury and stroke.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ASY; Foocen; Human NogoA; My043 protein; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; Nogo protein; NOGO-A; RTN4-A; NOGO-B; RTN4-B1; NOGO-C; RTN4-C; NSP; reticulon; Reticulon 4; reticulon 5; Reticulon-4; Reticulon-5; RTN-x; Rtn4; RTN4-Aa; RTN4-Ab; RTN4-B2; RTN4-D; RTN4-E; RTN4-F; RTN4-G; RTN4a; RTN4b; RTN4c; unnamed protein product
基因别名: ASY; KIAA0886; My043; Nbla00271; Nbla10545; NI220/250; NOGO; NSP; NSP-CL; RTN-X; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; SP1507
UniProt ID: (Human) Q9NQC3
Entrez Gene ID: (Human) 57142
blastocyst formation
leukocyte migration involved in inflammatory response
apoptotic process
endoplasmic reticulum organization
nervous system development
axonal fasciculation
brain development
positive regulation of epithelial cell migration
cerebral cortex radial glia guided migration
central nervous system vasculogenesis
neuron differentiation
negative regulation of cell growth
regulation of cell migration
negative regulation of axon extension
positive regulation of mammary gland epithelial cell proliferation
positive regulation of toll-like receptor 9 signaling pathway
positive regulation of Rac protein signal transduction
cell migration involved in vasculogenesis
regulation of apoptotic process
positive regulation of angiogenesis
modulation of synaptic transmission
protein stabilization
nuclear pore complex assembly
positive regulation of protein kinase B signaling
regulation of nervous system development
cardiac epithelial to mesenchymal transition
positive regulation of macrophage cytokine production
protein localization to lysosome
cellular response to hypoxia
endoplasmic reticulum tubular network organization
endoplasmic reticulum tubular network assembly
cellular sphingolipid homeostasis
cell adhesion involved in sprouting angiogenesis
regulation of postsynapse assembly
negative regulation of beta-amyloid formation
positive regulation of neutrophil migration
positive regulation of macrophage migration
positive regulation of protein localization to endoplasmic reticulum
positive regulation of ERBB3 signaling pathway
positive regulation of artery morphogenesis
endoplasmic reticulum tubular network membrane organization
regulation of branching morphogenesis of a nerve
positive regulation of hepatocyte proliferation
negative regulation of vasculogenesis
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