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Invitrogen

Nogo-B Recombinant Rabbit Monoclonal Antibody (K01_3W14)

查看其他4个Nogo-B抗体

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产品信息

MA567051

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

K01_3W14

抗原

A synthesized peptide derived from human Nogo.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 50% glycerol, 0.05% BSA, 150mM NaCl

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Nogo-B is a member of the reticulon-4 (RTN4) family of proteins, primarily localized to the endoplasmic reticulum and expressed in many tissues, especially vascular endothelial and smooth muscle cells. It plays a key role in regulating vascular remodeling, cell migration, and tissue repair by influencing cytoskeletal organization and signaling pathways. Unlike Nogo-A, which is known for inhibiting nerve regeneration, Nogo-B is more involved in maintaining vascular homeostasis and modulating inflammatory responses.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: ASY; Foocen; Human NogoA; My043 protein; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; Nogo protein; NOGO-A; RTN4-A; NOGO-B; RTN4-B1; NOGO-C; RTN4-C; NSP; reticulon; reticulon 5; Reticulon-4; Reticulon-5; RTN-x; RTN4-Aa; RTN4-Ab; RTN4-B2; RTN4-D; RTN4-E; RTN4-F; RTN4-G; RTN4a; RTN4b; RTN4c; unnamed protein product

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基因别名: ASY; KIAA0886; My043; Nbla00271; Nbla10545; NI220/250; NOGO; NSP; NSP-CL; RTN-X; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; SP1507

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UniProt ID: (Human) Q9NQC3

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Entrez Gene ID: (Human) 57142

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功能
RNA binding protein binding ubiquitin protein ligase binding protein homodimerization activity cadherin binding metal ion binding
参与通路
blastocyst formation leukocyte migration involved in inflammatory response apoptotic process endoplasmic reticulum organization nervous system development axonal fasciculation brain development positive regulation of epithelial cell migration cerebral cortex radial glia guided migration central nervous system vasculogenesis neuron differentiation negative regulation of cell growth regulation of cell migration negative regulation of axon extension positive regulation of mammary gland epithelial cell proliferation positive regulation of toll-like receptor 9 signaling pathway positive regulation of Rac protein signal transduction cell migration involved in vasculogenesis regulation of apoptotic process positive regulation of angiogenesis modulation of synaptic transmission protein stabilization nuclear pore complex assembly positive regulation of protein kinase B signaling regulation of nervous system development cardiac epithelial to mesenchymal transition positive regulation of macrophage cytokine production protein localization to lysosome cellular response to hypoxia endoplasmic reticulum tubular network organization endoplasmic reticulum tubular network assembly cellular sphingolipid homeostasis cell adhesion involved in sprouting angiogenesis regulation of postsynapse assembly negative regulation of beta-amyloid formation positive regulation of neutrophil migration positive regulation of macrophage migration positive regulation of protein localization to endoplasmic reticulum positive regulation of ERBB3 signaling pathway positive regulation of artery morphogenesis endoplasmic reticulum tubular network membrane organization regulation of branching morphogenesis of a nerve positive regulation of hepatocyte proliferation negative regulation of vasculogenesis
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