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Invitrogen
Nogo-B Monoclonal Antibody (523808)
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产品信息
MA5-61691
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
523808
抗原
Mouse myeloma cell line NS0-derived recombinant mouse Nogo-B., Met1-Ile183 (predicted)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
靶标信息
Nogo-B is a member of the reticulon-4 (RTN4) family of proteins, primarily localized to the endoplasmic reticulum and expressed in many tissues, especially vascular endothelial and smooth muscle cells. It plays a key role in regulating vascular remodeling, cell migration, and tissue repair by influencing cytoskeletal organization and signaling pathways. Unlike Nogo-A, which is known for inhibiting nerve regeneration, Nogo-B is more involved in maintaining vascular homeostasis and modulating inflammatory responses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Neurite outgrowth inhibitor; Nogo protein; Reticulon-4
基因别名: 1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; Kiaa0886; mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C; NSP-CL; Rtn4
UniProt ID: (Mouse) Q99P72
Entrez Gene ID: (Mouse) 68585
angiogenesis
nervous system development
axonogenesis
axonal fasciculation
negative regulation of neuron projection development
cerebral cortex radial glia guided migration
negative regulation of cell growth
regulation of cell migration
negative regulation of axon extension
positive regulation of dopamine secretion
negative regulation of neuron differentiation
positive regulation of glial cell differentiation
negative regulation of axonogenesis
regulation of sensory perception of pain
regulation of nervous system development
cardiac epithelial to mesenchymal transition
negative regulation of neuron projection regeneration
endoplasmic reticulum tubular network organization
regulation of branching morphogenesis of a nerve
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