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Rockland
NogoA Polyclonal Antibody
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产品信息
600-401-C01
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human NogoA protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS, blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Foocen; Glut4 vesicle 20 kDa protein; GLUT4 vesicle 20kDa protein; Human NogoA; My043 protein; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; NI-220/250; Nogo protein; NSP; reticulon 5; Reticulon-4; Reticulon-5; RTN-x
基因别名: 1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; KIAA0886; mKIAA0886; mKIAA4153; My043; Nbla00271; Nbla10545; NgA; NI-250; NI220/250; NOGO; NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; r; rat N; rat NogoA; RTN-X; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; SP1507; Vp20
UniProt ID: (Human) Q9NQC3, (Mouse) Q99P72, (Rat) Q9JK11
Entrez Gene ID: (Human) 57142, (Mouse) 68585, (Rat) 83765
angiogenesis
nervous system development
axonogenesis
axonal fasciculation
negative regulation of neuron projection development
cerebral cortex radial glia guided migration
negative regulation of cell growth
regulation of cell migration
negative regulation of axon extension
positive regulation of dopamine secretion
negative regulation of neuron differentiation
positive regulation of glial cell differentiation
negative regulation of axonogenesis
regulation of sensory perception of pain
regulation of nervous system development
cardiac epithelial to mesenchymal transition
negative regulation of neuron projection regeneration
endoplasmic reticulum tubular network organization
regulation of branching morphogenesis of a nerve
apoptotic process
regulation of apoptotic process
nuclear pore complex assembly
endoplasmic reticulum tubular network assembly
cell-cell adhesion
aging
response to activity
olfactory nerve development
oligodendrocyte differentiation
